John Arnott, PhD

John Arnott’s research focuses on the molecular signaling mechanisms in osteoblasts that regulate bone formation and fracture repair. His work aims to understand how bone growth factors—particularly connective tissue growth factor (CTGF/CCN2)—control osteoblast differentiation and function, as well as how CTGF expression is regulated by other signaling pathways. By elucidating the cellular and molecular processes underlying skeletal development and bone formation, his research seeks to identify potential therapeutic targets for enhancing bone regeneration and treating clinically significant bone loss, including osteoporosis.